ParkinsonCanadaV1, Main, Exploration, bibRecord, 003330

Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease

Identifieur interne : 003330 ( Main/Exploration ); précédent : 003329; suivant : 003331

Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease

Auteurs : B. M. Ross [Canada] ; N. Mamalias [Canada] ; A. Moszczynska [Canada] ; A. H. Rajput [Canada] ; S. J. Kish [Canada]

Source :

Neuroscience [ 0306-4522 ] ; 2001.

RBID : Pascal:01-0144147

Descripteurs français

Pascal (Inist)
- Phospholipide, Biosynthèse, Activité enzymatique, Locus niger, Stress oxydatif, Parkinson maladie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Biosynthesis, Cell Membrane (enzymology), Choline-Phosphate Cytidylyltransferase (metabolism), Cytidine Diphosphate Choline (metabolism), Enzymatic activity, Enzyme Activation (physiology), Ethanolamines (metabolism), Female, Human, Humans, Locus niger, Male, Oxidative Stress (physiology), Oxidative stress, Parkinson Disease (metabolism), Parkinson disease, Phospholipases A (metabolism), Phospholipases A2, Phospholipid, Phospholipids (biosynthesis), Phosphorylcholine (metabolism), Substantia Nigra (enzymology).
MESH :
- chemical , biosynthesis : Phospholipids.
- chemical , metabolism : Choline-Phosphate Cytidylyltransferase, Cytidine Diphosphate Choline, Ethanolamines, Phospholipases A, Phosphorylcholine.
- enzymology : Cell Membrane, Substantia Nigra.
- metabolism : Parkinson Disease.
- physiology : Enzyme Activation, Oxidative Stress.
- Aged, Aged, 80 and over, Female, Humans, Male, Phospholipases A2.

Abstract

We reported that the activities of phospholipase A₂, phosphocholine cytidylyltransferase and phosphoethanol-amine cytidylyltransferase, key phospholipid metabolic enzymes, are low in substantia nigra of normal human brain and that this might reduce the ability of nigral neurons to repair damage to cell membranes. To determine whether adaptive changes in nigral phospholipid metabolism can occur in idiopathic Parkinson's disease we compared activities of I 1 catabolic and anabolic enzymes in autopsied brain of 10 patients with Parkinson's disease to those in control subjects. Nigral activity of the catabolic enzyme phospholipase A₂ was normal in the Parkinson's disease group, whereas that of the biosynthetic enzymes phosphoethanolamine cytidylyltransferase, phosphocholine cytidylyltransferase, and phosphatidylserine synthase were elevated 193, 48 and 38%, respectively, possibly representing a compensatory response to repair membrane phospholipids. Enzyme activities were normal in all other brain areas with the exception of increased (+26%) activity of calcium-stimulated phospholipase A₂ in putamen, a change which could he consequent to either decreased dopaminergic striatal input or to a dopamine nerve terminal degenerative process. Our data indicate that the normally low rate of membrane phospholipid synthesis in the substantia nigra, the primary area of neurodegeneration in Parkinson's disease, is increased during the course of the disorder. We suggest that pharmacotherapies which augment this compensatory response might have utility as a treatment for Parkinson's disease.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">We reported that the activities of phospholipase A<sub>2</sub>
, phosphocholine cytidylyltransferase and phosphoethanol-amine cytidylyltransferase, key phospholipid metabolic enzymes, are low in substantia nigra of normal human brain and that this might reduce the ability of nigral neurons to repair damage to cell membranes. To determine whether adaptive changes in nigral phospholipid metabolism can occur in idiopathic Parkinson's disease we compared activities of I 1 catabolic and anabolic enzymes in autopsied brain of 10 patients with Parkinson's disease to those in control subjects. Nigral activity of the catabolic enzyme phospholipase A<sub>2</sub>
 was normal in the Parkinson's disease group, whereas that of the biosynthetic enzymes phosphoethanolamine cytidylyltransferase, phosphocholine cytidylyltransferase, and phosphatidylserine synthase were elevated 193, 48 and 38%, respectively, possibly representing a compensatory response to repair membrane phospholipids. Enzyme activities were normal in all other brain areas with the exception of increased (+26%) activity of calcium-stimulated phospholipase A<sub>2</sub>
 in putamen, a change which could he consequent to either decreased dopaminergic striatal input or to a dopamine nerve terminal degenerative process. Our data indicate that the normally low rate of membrane phospholipid synthesis in the substantia nigra, the primary area of neurodegeneration in Parkinson's disease, is increased during the course of the disorder. We suggest that pharmacotherapies which augment this compensatory response might have utility as a treatment for Parkinson's disease.</div>
</front>
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La maladie de Parkinson au Canada (serveur d'exploration)

Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease

Elevated activity of phospholipid biosynthetic enzymes in substantia nigra of patients with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.